The quantification of large therapeutic peptides has traditionally been handled using Ligand Binding Assays, however with the advancement of technology platforms, additional options for the quantification are available, including LC-MS/MS.
The use of LC-MS/MS for the analysis of peptides has shown multiple opportunities compared to certain Ligand Binding Assay (LBA) challenges and it is an approach that is well accepted by Regulatory Agencies. Algorithme Pharma scientists have developed several LC-MS/MS methods for the analysis of peptides overcoming:
Using sample enrichment techniques, highly selective extractions, improved chromatography with specific additives to generate narrow chromatographic peaks and enhance ionization, and state-of-the-art MS approaches, we are able to provide you with the right selectivity & sensitivity for quantifying your peptides.
Our Mass Spectrometry and Ligand Binding Bioanalysis teams, led by Dr. Fabio Garofolo and Dr. Robert Massé respectively, with over 100 full-time specialized chemists and analysts, have the dedicated technology platforms to meet your drug quantification needs, along the full range of molecule size, and consistently provide their scientific expertise, competitive timelines and outstanding quality in all the studies we conduct.
To learn more about our bioanalytical services, please contact us at: