2014 AAPS Annual Meeting Poster Sessions
San Diego, CA - Booth # 2741

Algorithme Pharma is a clinical contract research organization (CRO) with over 20 years of experience. We provide services for the pharmaceutical, biotechnology and generic drug industries.

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01:30 p.m. - 05:00 p.m.:

  • Poster M1326: A Comparative Pharmacokinetic Study of Omeprazole in a Fixed-Dose Combination Capsule of Meloxicam/Omeprazole Compared to the Individual Omeprazole Capsule in Healthy Adult Volunteers under Fed Conditions

    Authors: Julie Massicotte, Audrey Fortier, Sylvie Boily, Jean-Michel Paquette, Laura Sayegh, Eric Sicard, Marc Lefebvre, Jiri Hofmann

  • Poster M1317: Retrospective Analysis of Mesalamine Delayed-Release Tablets in Healthy Males and Females Volunteers: Effects of Food and Gender on Pharmacokinetic Parameters

    Authors: Sophie Boudriau, Michael Boily, Julie Massicotte, Pascal Guibord, Marc Lefebvre

09:30 a.m. - 12:30 p.m.:

  • Poster T2255: Application and Advantages of HRMS in the Quantification of Therapeutic Monoclonal Antibodies: The Rituximab Case Study

    Authors: K. Mekhssian, J.N. Mess, Fabio Garofolo

  • Poster T2256: Internal Standardization Approaches for the Quantification of a 25 kDa Fusion Protein to Support Early Stage Drug Development by LC-MS

    Authors: J.N. Mess, K.R. Erlemann, J. Pieczykolan, S. Pawlak, Fabio Garofolo

  • Poster T2257: Impact of Oxidative Modifications on the Quantification of Intact Therapeutic Proteins by High Resolution Mass Spectrometry

    Authors: L.P. Morin, Fabio Garofolo

  • Poster T2258: Liquid Chromatography-High Resolution Mass Spectrometry Bioanalytical Approach for the Quantification of Total Antibody-Drug Conjugate (ADC, DAR&[ge]0) in Rat Plasma

    Authors: J.N. Mess, Suma Ramagiri, Gary Impey, Fabio Garofolo

  • Poster T2259: Quantification of Growth Hormone Receptor Antagonist Pegvisomant by LC-MS/MS in Rat Plasma: Method Development Considerations for PEGylated Proteins

    Authors: J. R. St-Germain, J.N. Mess, Fabio Garofolo

  • Poster T2260: Strategies to Eliminate Anti-Drug Antibody (ADA) Interference due to Immunogenicity on Large Molecule Quantification by LC-MS/MS

    Authors: D. Villeneuve, JN Mess, Fabio Garofolo

  • Poster T2363: Single-Dose Pharmacokinetics of Deferiprone in Subjects with Various Degrees of Renal Impairment

    Authors:Submission Authors: Josee Michaud, Jean-Michel Paquette, Rachida Essalihi, Mira Francis, Sylvie Boily, Julie Massicotte, Marc Lefebvre, Eric Sicard, Vincent Pichette, Yu Chung Tsang, Caroline Fradette

01:30 p.m. - 05:00 p.m.:

  • Poster T3252: A GLP Butyrylclolinesterase (BCHE) Assay: Validation and Application in Rivastigmine Clinical Studies

    Authors: Martin Clement, Thu Bich Vu, Susana Liu, Robert Masse

  • Poster T3350: Personalized Characterization of New Drug Entities: Integration of Pharmacogenetics in Phase I Clinical Programs for an Accelerated Drug Development

    Authors: Mira Francis, Catherine Dussault, Julie Massicotte, Eric Sicard, Marc Lefebvre

01:30 p.m. - 04:30 p.m.:

  • Poster W5222: Evaluation of the Budesonide 22R and 22S Epimers Fragmentation in LC-MS/MS and its Impact in Quantitative Bioanalysis

    Authors: Eugenie-Raphaelle Berube, Sylvain Latour, Milton Furtado, Fabio Garofolo

  • Poster W5223: Troubleshooting and Real Time Monitoring of Matrix Effect Generated by Consumable Labware during Ivermectin Quantification by LC-MS/MS.

    Authors: Mathieu Lahaie, Kevork Mekhssian, Romain Beauvois, Georges Koudssi, Milton Furtado, Fabio Garofolo

  • Poster W5224: Impact of Plasma Hemolysis on the Recovery of Phenprocoumon in LC-MS/MS Chiral Assay

    Authors: Nikolay Youhnovski, Romain Beauvois, Mathieu Lahaie, Milton Furtado, Fabio Garofolo

  • Poster W5225: In Depth Evaluation of a Novel On-line HybridSPE Technology for Removal of Phospholipids from Protein Precipitation Plasma Samples by LC-MS/MS

    Authors: Laurence Mayrand-Provencher, Richard Lavallee, Milton Furtado, David Bell, Fabio Garofolo

  • Poster W5226: How to Prevent Changes in Plasma Integrity and Its Impact on LC-MS/MS Bioanalysis Due to Organic Solvent and Storage Conditions

    Authors: Romain Beauvois, Silvana Olivieri, Milton Furtado, Fabio Garofolo

  • Poster W5227: Parallelism Comparison between Surrogate and Biological Matrix for the Quantification of Endogenous Levels Using Surrogate Matrix Calibration Curve by LC-MS/MS

    Authors: Richard Lavallee, Milton Furtado, Fabio Garofolo

  • Poster W5228: Post-Column Addition of High pH Solution to Improve Analyte Sensitivity and Avoid On-Column Degradation of Unstable Metabolites in LC-MS/MS

    Authors: Laurence Mayrand-Provencher, Julien Nantel, Milton Furtado, Fabio Garofolo

  • Poster W5229: In Depth Bioanalytical Investigation and Root Cause Analysis of Lamotrigine Severe Degradation in Hemolyzed Plasma Samples by LC-MS/MS

    Authors: Nicolaos Soilis, Richard Lavallee, Milton Furtado, Fabio Garofolo

  • Poster W5274: Safety, Tolerability and Pharmacokinetics of GIC-1001 in a Randomized Phase I Integrated Design Study: Single and Multiple Ascending Doses, Effect of Food, with Healthy Volunteers

    Authors: Jean-Michel Paquette, Marianne Rufiange, Julie Massicotte, Aziz Ait Sadoune, Eric Sicard, Marc Lefebvre, Patrick Colin, Maxime Ranger

08:30 a.m. - 11:30 a.m.:

  • Poster R6309: Validation of a Kinetics Factor Xa GLP Assay for Heparin Quantitation in Human Plasma

    Authors: Lillian Mottley, Martin Clement, Stephen Wallace, Thu Bich Vu, Susana Liu, Robert Masse

  • Poster R6353: Assessment of the Updated Regulations from Health Canada on the Clinical Trial Application Review Process and Timelines

    Authors: Ani Matian, Julie Massicotte, Marc Lefebvre

Journal publication:

September 15, 2014

Clinical Therapeutics, September 2014

Safety, Tolerability and Pharmacokinetics of Trimebutine 3-Thiocarbamoylbenzenesulfonate (GIC-1001) in a Randomized Phase I Integrated Design Study: Single & Multiple Ascending Doses, Effect of Food, with Healthy Volunteers.


Press Releases:

March 26, 2014

Algorithme Pharma Presents at Quebec Drug Development Symposium

During a recent drug development symposium held at the NEOMED Institute in Montreal, Dr. Marc Lefebvre, Vice-President Scientific & Regulatory Affairs, Algorithme Pharma Inc., addressed life science executives on developing efficient First-In-Human (FIH) clinical trials to help reduce costs and shorten the timeline for approval of new drugs.